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Journal of Pharmacology and Toxicology
Year: 2011  |  Volume: 6  |  Issue: 1  |  Page No.: 30 - 48

Hepatoprotective Effects of Clitoria ternatea and Vigna mungo against Acetaminophen and Carbon tetrachloride-induced Hepatotoxicity in Rats

Y.B. Solanki and S.M. Jain    

Abstract: The present study was undertaken to investigate hepatoprotective activity of Clitoria ternatea seed and root and Vigna mungo seed against acetaminophen- and carbon tetrachloride-intoxicated rats. The liver functioning was evaluated by measuring serum marker enzymes and hepatic fibrosis was accessed by measuring collagen content in terms of p-hydroxyproline levels. Mast cell infiltration and potentiation of phenobarbitone-induced sleeping time were also measured. In addition, serum bilirubin, creatinine, lipid peroxidation and antioxidant parameters were also estimated. C. ternatea and V. mungo seed extracts significantly (p<0.05) decreased SGOT, SGPT, ALP and total bilirubin in both acetaminophen and CCl4 - intoxicated rats. The C. ternatea root extract, showed similar results only in CCl4 - intoxicated rats. These findings were further supplemented by histopathological studies of liver tissues. Hepatic collagen content as evident from decreased (p<0.05) hydroxyproline levels and hepatic mast cell infiltration were significantly decreased in extracts pre-treated animals. In addition, C. ternatea and V. mungo seed extracts significantly (p<0.05) reduced hepatic lipid peroxidation as evident from the decreased MDA, increased antioxidant enzymes activities and GSH levels in the liver tissues. The V. mungo seed extract significantly potentiated barbiturate-induced sleeping time. The findings of study suggested that C. ternatea and V. mungo possess potent hepatoprotective activity. The hepatoprotective activity of C. ternatea could be attributed to antioxidant properties and prevention of pre-inflammatory changes. The hepatoprotective activity of V. mungo could be attributed partly to the hepatic microsomal enzyme inhibition and partly to the antioxidant properties.

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