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Journal of Pharmacology and Toxicology
Year: 2011  |  Volume: 6  |  Issue: 2  |  Page No.: 149 - 157

Biological and Toxicological Effects of Aqueous Acetone Extract of Cienfuegosia digitata Cav. (Malvaceae) in Mice and Rats

K. Konate, A. Souza, M. Lamidi, J.F. Djoba Siawaya, F.H. Ella Mendene, J. Millogo-Rasolodimby and O.G. Nacoulma    

Abstract: Cienfuegosia digitata Cav., one specie of family of Malvaceae and a herbal plant well known in traditional medicine in Burkina Faso to treat infectious disease particularly hepatitis B. The present study was conducted to evaluate the biological and toxic effects of aqueous acetone extract of Cienfuegosia digitata Cav. in mice Swiss and albinos Wistar rats. In acute toxicity test, mice received doses of this extract by intraperitoneal route with LD50 value of 601.8 mg kg-1. In sub-acute toxicity test, albinos Wistar rats were treat by gavage during 28 days with different doses of aqueous acetone extract of Cienfuegosia digitata Cav. (25, 50, 100 mg kg-1). In biological parameters evaluations, the results varied widely in dose of extract and weight of rats and did not show clinical correlations. We undertook this study of extract in order to provide a scientific basis for the traditional use of Cienfuegosia digitata Cav. in traditional medicine. Present results of this study appeared to show the safety of acute and sub-acute toxicities of extract from of Cienfuegosia digitata Cav. which can therefore be continuously used with safety in traditional medicine. Statistical studies revealed that there is a low significant difference in body and organ weights and biological parameters between control group and the treated assay groups (p<0.01 or p<0.05).

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