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Journal of Pharmacology and Toxicology
Year: 2010  |  Volume: 5  |  Issue: 2  |  Page No.: 46 - 54

Administration Senna occidentalis Seeds to Adult and Juvenile Rats: Effects on Thymus, Spleen and in Hematological Parameters

D.P. Mariano-Souza, C.A. Paulino, P.C. Maiorka and S.L. Gorniak    

Abstract: The effects of daily administration of Senna occidentalis (So) seeds in various concentrations [1% (So1), 2% (So2) and 4% (So4)] to animal feed were investigated in adult and juvenile rats. Additionally, this study evaluated the effects of the same amount of feed without So, seeds on rats (PF-rats). Food consumption and body weight gain were evaluated during 14 day. Moreover, hematological parameters, lymphoid organ weight and histopathology were also performed. We found major alterations in the follow parameters: diminished in food consumption in all treated So adult rats, reduction in the total body weight gain in both adult and juvenile rats from So2 and So4 groups. Lymphoid organs evaluation revealed that So seeds can induce immunotoxic effect on thymus and splenomegaly in adult and juvenile rats. These results provide the first evidence that S. occidentalis has a direct toxic effect in thymus how a target organ in mammals and suggested that alterations in lymphoid organs are probably associated with the direct toxic effects of this plant and are not due to malnutrition.

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