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Journal of Pharmacology and Toxicology
Year: 2009  |  Volume: 4  |  Issue: 5  |  Page No.: 205 - 212

Study on Release Pattern and Potency Status of Ketoprofen Solid Dosage Forms Available in the Pharma-Market of Bangladesh

M.E. Ali, M.A. Salam, M.A. Asad and M. Saifuzzaman    

Abstract: Ketoprofen, a widely used analgesic drug is available in two solid dosage forms in the pharma-market of Bangladesh: enteric-coated tablet and capsule of sustained-release pattern. Seven brands of ketoprofen enteric-coated tablets and four brands of ketoprofen sustained release capsules were studied for their in vitro release behavior as well as potency status. From the seven samples of tablets, two brands (KT-03 and KT-07) were found noncompliant in respect of disintegration test in acid stage, whereas all the brands complied with BP (British Pharmacopoeia) specification in buffer stage at pH 6.8. The dissolution study of ketoprofen tablets were carried out in both acid and buffer stages and all the samples satisfied with USP specification in both stages. All of the brands of ketoprofen capsule also complied with the USP specification. Potency was determined by UV spectroscopic method according to BP. Two brands (KT-03 and KT-07) of tablets were found non-compliant, whereas all the brands of capsules exerted compliance in respect of potency.

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