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Journal of Pharmacology and Toxicology

Year: 2009  |  Volume: 4  |  Issue: 4  |  Page No.: 160 - 166

Protective Effect of Moringa oleifera Lam. and Lannea kerstingii Extracts Against Cadmium and Ethanol-induced Lipid Peroxidation

A. Diallo, K. Eklu-Gadegkeku, T. Mobio, S. Moukha, A. Agbonon, K. Aklikokou, E.E. Creppy and M. Gbeassor


The present study had evaluated the protective effect of hydroalcoholic (50-50: v/v) and aqueous extracts of L. kerstingii and M. oleifera against lipid peroxidation induced in vivo and in vitro by either cadmium or ethanol. In a first series of experiments, lipid peroxidation induced in vitro by cadmium (5 μg mL-1) is decreased by hydroalcoholic extracts of M. oleifera and L. kerstingii (100 μg mL-1) by 94% and 50% (p<0.001) respectively whereas their aqueous extracts (100 μg mL-1) reduced the cadmium induced lipid peroxidation by 94% (p<0.001) and 44% (p<0.001) respectively. In vivo, the pretreatment with hydroalcoholic extracts of M. oleifera and L. kerstingii at 1 g kg-1 b.wt. reduced significantly ethanol-induced lipid peroxidation, in liver, by 53 and 50% (p<0.001), respectively. Similar results were found in the kidney even though lipid peroxidation is slightly increased by ethanol in this organ.

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