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Journal of Pharmacology and Toxicology
Year: 2009  |  Volume: 4  |  Issue: 3  |  Page No.: 107 - 116

Nephrotoxicity Reduction by Ceftriaxone plus Vancomycin (Vancoplus) Reconstituted with VRP 1020 in Blood of Mus musculus Mice

Arvind Soni, Manu Chaudhary and Vivek Kumar Dwivedi    

Abstract: The aim of the present study was to evaluated the effect of the VRP 1020 in reconstitution with fixed dose combination of ceftriaxone-vancomycin (Vancoplus). The mice were fed standard pelleted diet and water ad libitum. The test room was air conditioned with temperature 23±20°C, humidity 65±5% and with artificial fluorescent light (10-14 h) of light and dark, respectively. Thirty Mus musculus mice (weighing 30±5 g) were divided into 5 groups containing 6 mice in each group. Group I: control (normal saline), group II: ceftriaxone (28.57 mg kg-1 body weight/day) group III: vancomycin (14.2 mg kg-1 body weight/day), group IV: ceftriaxone-vancomycin (42.8 mg kg-1 body weight/day) and group V: ceftriaxone-vancomycin+VRP 1020 (42.8 mg kg-1 body weight/day). Present finding showed that activities of antioxidant enzymes (superoxide dismutase and catalase) and pyridoxal-5-phosphate level (biologically most active co-enzyme of vitamin B6) were significantly increased along with decreased in lipid peroxidation (malonaldialdehyde) level in vancoplus treated group as compared to ceftriaxone and vancomycin alone and combination of ceftriaxone-vancomycin treated group. Similarly, the levels of extracellular antioxidant (creatinine and uric acid) were found to be significant lowered in vancoplus treated group when compared to ceftriaxone, vancomycin and ceftriaxone-vancomycin treated group. These results indicated that reconstitution of VRP 1020 with fixed dose combination of ceftriaxone-vancomycin protects against ceftriaxone and vancomycin induced nephrotoxicity that improved the activities of free radical scavenging enzymes.

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