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Journal of Pharmacology and Toxicology
Year: 2008  |  Volume: 3  |  Issue: 6  |  Page No.: 471 - 477

Effects of Folic Acid and Vitamin C on Arsenic Induced Mice

M.E. Ali, M.A. Salam, M.A. Asad, M. Saifuzzaman and M.M. Sarder    

Abstract: In this study, 5 weeks old mice weighing 22±2 g were grouped in four, each group consisting of six animals. Group-I, II, III and IV of the animals were fed by a standard diet quantity sufficient, normal diet with dissolved arsenic, arsenic with folic acid mixed and arsenic with vitamin C mixed, respectively. Blood was collected from the sacrificed animals and the blood glucose levels were determined by spectrophotometrically and glucometer. The average blood glucose level of arsenic induced animals was 9.37 mmol L-1 compared to 6.53 mmol L-1 in control animals whereas the blood glucose level of Group-III and Group-IV were 6.73 and 7.03 mmol L-1, respectively. Weight gain of the arsenic induced animals was lower compared to that of the animals fed with normal diet, folic acid mixed diet or vitamin C mixed diet. After sacrifice, the weight of kidney, heart and lung of arsenic induced animals were less than that of the Group-III and Group-IV. The reduction of arsenic induced higher blood glucose level by folic acid and vitamin C demonstrates that folic acid and vitamin C has significant effect in preventing arsenic induced disease.

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