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Journal of Pharmacology and Toxicology
Year: 2008  |  Volume: 3  |  Issue: 5  |  Page No.: 409 - 413

Pharmacodynamic Drug Interaction of Metformin with Statins in Rats

N. Anitha, J.V. Rao, S. Kavimani and V. Himabindu    

Abstract: The present study is aimed to explore the pharmacodynamic interaction of metformin with statins like atorvastatin and rosuvastatin in rats. Wistar albino rats of either sex (150-200 g) were induced diabetes by administering alloxan and they were divided into six groups, each consisting of six rats. Normal control group (1) is treated with 1%w/v carboxy methyl cellulose (CMC) suspension. Group 2 served as diabetic control. To the diabetic 3rd, 4th and 5th group metformin, atorvastatin and rosuvastatin were administered orally respectively for 7 days. The combination of metformin + atorvastatin and metformin + rosuvastatin were administered to the 6th and 7th group of diabetic rats for 7 days. On the last day blood samples were collected, serum was isolated and subjected to glucose, triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL) and high density lipoprotein (HDL) estimation. Body weight was also calculated. Metformin significantly reduced the serum glucose level in diabetic rats. Atorvastatin and rosuvastatin produced mild hypoglycemia. On the other hand the combination of metformin + atorvastatin and metformin + rosuvastatin significantly reduced the serum glucose level when compared to metformin alone. Atorvastatin and rosuvastatin significantly reduced the serum TG, TC and LDL and increased HDL level. Metformin also altered the lipid profile of diabetic rats. Whereas the combination of metformin + atorvastatin and metformin + rosuvastatin significantly reduced the lipid profile when compared to atorvastatin and rosuvastatin alone. The combination of drugs also increased the body weight of diabetic animals. The antidiabetic drug metformin enhanced the hypolipidemic activity of atorvastatin and rosuvastatin. Similarly atorvastatin and rosuvastatin enhanced the hypoglycemic activity of metformin due to pharmacodynamic interactions.

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