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Journal of Pharmacology and Toxicology
Year: 2008  |  Volume: 3  |  Issue: 5  |  Page No.: 344 - 350

Antioxidant and Hepatoprotective Activity of Ethanol Extract of Indigofera trita Linn. on CCl4 Induced Hepatotoxicity in Rats

Raju Senthil Kumar, Rangasamy Manivannan, Ayyasamy Balasubramaniam and Balasubramanian Rajkapoor    

Abstract: The ethanol extract of Indigofera trita (EIT) was studied for its antioxidant and hepatoprotective properties. The ethanol extract exhibited potent in vitro antioxidant activity as evidenced by the low IC50 values in the scavenging of ABTS, DPPH and hydroxyl radical methods. The IC50 values obtained were 9.50 ± 0.50 and 19.91 ± 1.73 μg mL-1, respectively for ABTS and DPPH methods. The IC50 values obtained for hydroxyl radical scavenging by p-NDA and deoxyribose methods were found to be 104.50 ± 4.50 and 99.00 ± 0.28 μg mL-1, respectively. The treatment with the EIT at 200 and 400 mg kg-1 body weight showed a significant and dose dependent decrease in the levels of SGOT, SGPT, ALP and TBARS and significant increase in the levels of albumin, total protein, SOD and catalase, when compared to CCl4 treated rats. The treatment with EIT exhibited better results than the standard vitamin-E treatment in some of these parameters. Thus, the EIT showed significant antioxidant and hepatoprotective activity. These results were also confirmed by the histological observation.

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