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Journal of Pharmacology and Toxicology
Year: 2008  |  Volume: 3  |  Issue: 4  |  Page No.: 324 - 329

In vivo Antiplasmodial Activity and Acute Toxicity of the Fraction of the Garcinia parvifolia Miq. Stem Bark

Syamsudin, Soesanto Tjokrosonto, Subagus Wahyuono and Mustofa    

Abstract: The study of in vivo antiplasmodial activity and acute toxicity of the active fraction of Garcinia parvifolia Miq. has been conducted. The fraction was obtained by maceration of n-hexane extract with methanol. A standard 4-day test on P. berghei infected Swiss mice was used to evaluate the in vivo antiplasmodial activity after an oral administration of the fraction in series dose of 25 to 200 mg kg-1 b.wt. once daily for 4 consecutive days. The in vivo antiplasmodial activity was expressed by the dose inhibiting 50% of parasite growth (ED50). Acute toxicity was evaluated in Swiss mice after oral administration of the active fraction in series dose of 2000 to 8000 mg kg-1 b.wt. The acute toxicity was expressed by the dose leading 50% deaths (LD50). The results showed that the active fraction of G. parvifolia Miq. was active against P. berghei in mice with an ED50 of 74.45 mg kg-1 b.wt. day-1. In addition, the active fraction was also relatively safe as expressed by the LD50 of 8000 mg kg-1 b.wt.

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