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Journal of Pharmacology and Toxicology
Year: 2008  |  Volume: 3  |  Issue: 3  |  Page No.: 236 - 240

Effect of Chloroquine Sensitive Plasmodium berghei in Pregnant Mice

A.C. Ene, T.M. Adisa, E.A. Nwankwo and P.U. Agomo    

Abstract: Pregnant mice were examined to determine whether or not they transmitted Plasmodium berghei to their fetuses. On the 14th day of pregnancy, mice were inoculated with approximately 3x106 P. berghei infected red blood cells by intraperitoneal injection. The parasitemia in 20 adult females and 145 neonates was assessed using thin blood films fixed with methanol and stained with 10% giemsa solution. The average parasitemia of females at delivery was 7.5%. Malaria parasites were microscopically confirmed in 8 of the 145 neonates. Maternal parasitemia at the time of delivery was not correlated with the incidence of vertical infection (8.71%). Present study showed that this model may be used to examine vertical transmission of malaria.

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