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Journal of Pharmacology and Toxicology
Year: 2008  |  Volume: 3  |  Issue: 3  |  Page No.: 190 - 202

Ultrastructural and Biochemical Abnormalities in the Liver of Streptozotocin-Diabetic Rats: Protective Effects of Murraya koenigii

P. Arulselvan and S. Subramanian    

Abstract: The objective of the present study is to evaluate the antioxidant potential of ethanolic extract of Murraya koenigii leaf on enzymatic, non enzymatic antioxidants and ultrastructural changes in liver of streptozotocin (STZ) induced diabetic rats. Effect of oral administration of M. koenigii leaves extract (200 mg kg-1 body weight) on the levels of blood glucose, plasma insulin, glycosylated hemoglobin, Thiobarbituric Acid Reactive Substances (TBARS), hydroperoxides, enzymatic and non-enzymatic antioxidants were estimated in STZ induced diabetic rats. Ultrastructural changes in the liver were also examined. Glibenclamide was used as a standard drug. The elevated levels of blood glucose, glycosylated hemoglobin, TBARS, hydroperoxides and decreased level of insulin observed in diabetic rats were significantly altered after treatment with the M. koenigii. The altered enzymatic and non-enzymatic antioxidants in the liver of streptozotocin induced diabetic rats, were restored to near normal levels by treatment with the M. koenigii leaves extract. Ultrastructure analysis of the liver of diabetic rat revealed a reduction in the Rough Endoplasmic Reticulum (RER) and swelling of mitochondria in the hepatocytes and these abnormalities were restored to near normal morphology by the treatment of rats with M. koenigii leaf extract. Our results suggested that the ethanolic extract of M. koenigii possess potent antioxidant properties which may be due to the presence of biologically active ingredients such as carbazole alkaloids, glycosides, triterpenoids and phenolic compounds. Thus the hepatoprotective and antidiabetic properties of M. koenigii leaves were probably of its antioxidant property.

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