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Journal of Pharmacology and Toxicology
Year: 2007  |  Volume: 2  |  Issue: 6  |  Page No.: 559 - 566

Effect of Sesbania grandiflora on Membrane-bound ATPases in Cigarette Smoke Exposed Rats

T. Ramesh, R. Mahesh and V. Hazeena Begum    

Abstract: The aim of present study to assesse the harmful effects of chronic cigarette smoking on membrane-bound ATPases and the protective effect of S. grandiflora in rat lung, liver, kidney and heart. Adult male WKY rats were exposed to cigarette smoke for a period of 90 days and consecutively treated with aqueous suspension of S. grandiflora (1000 mg kg-1 b.w/day, p.o) for a period of 3 weeks. The levels of lipid peroxides as marker for evaluating the extent of membrane damage, the activities of Na+-K+-ATPase, Ca2+-ATPase and Mg2+-ATPase and associated cations sodium (Na+), potassium (K+), calcium (Ca2+) and magnesium (Mg2+) were investigated in rat lung, liver, kidney and heart. Membrane damage was evident from the increased levels of lipid peroxides, decreased activities of membrane-bound ATPases and alterations in the levels of inorganic cations were observed in cigarette smoke exposed rats. Administration of aqueous suspension of S. grandiflora (ASSG) inhibited the levels of lipid peroxides, ameliorated the activities of membrane-bound ATPases and maintained the ionic equilibrium in rats exposed to cigarette smoke. The results of our study indicate that ASSG protects the membrane-bound ATPases from cigarette smoking induced membrane damage.

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