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Journal of Pharmacology and Toxicology
Year: 2007  |  Volume: 2  |  Issue: 1  |  Page No.: 44 - 53

Evaluation of Anti-inflammatory Activity of Cleome gynandra L. Leaf Extract on Acute and Chronic Inflammatory Arthritis Studied in Rats

R.T. Narendhirakannan, S. Subramanian and M. Kandaswamy    

Abstract: The present study was aimed to evaluate the anti-inflammatory potential of Cleome gynandra leaf extract on both acute (carrageenan induced paw edema) and chronic (cotton pellet granuloma) experimental inflammatory models induced in rats. The effect of C. gynandra on adjuvant induced arthritis was also evaluated. The extract at a dose of 150 mg kg-1 body weight was found to possess significant anti-inflammatory activity in all the experimental models and the results were comparable with indomethacin, a standard reference drug. The extract significantly decreased the carrageenan induced paw edema and cotton pellet granuloma. The increased activities of acid and alkaline phosphatase activity and decreased serum level albumin in cotton pellet granulomatous rats were reverted back to near normal levels after treatment with the extract. The extract significantly decreased the lipid peroxide (LPO) content of exudates, liver and spleen and the activity of γ-glutamyl transpeptidase in the exudates of cotton pellet granuloma. Moreover, C. gynandra also significantly suppressed the development of chronic arthritis induced by Freund`s complete adjuvant. These results demonstrated that the ethanolic extract of Cleome gynandra possess anti-inflammatory activity on both acute and chronic inflammation.

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