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Journal of Pharmacology and Toxicology
Year: 2007  |  Volume: 2  |  Issue: 3  |  Page No.: 264 - 270

Zinc oxide (ZnO): An Efficient Catalyst for the Synthesis of 4-arylmethylidene-2-phenyl 5(4H)-oxazolones Having Antimicrobial Activity

M.A. Pasha, V.P. Jayashankara, K.N. Venugopala and Gopal Krishna Rao    

Abstract: A straightforward and a general method has been developed for the synthesis of some important functionalized 4-arylmethylidene-2-phenyl-5(4H)-oxazolone derivatives by combining araldehydes and hippuric acid in the presence of catalytic amount of zinc oxide at room temperature in ethyl alcohol is reported. The method was very easy, rapid and products obtained were in excellent yields. The compounds were purified, characterized and were subjected for in vitro antibacterial activity (determination of Minimum Inhibitory Concentration (MIC) by micro titration method) using two standard drugs Streptomycin and Ampicillin against Bacillus subtilis and Escherichia coli. Five of the synthesized compounds showed remarkable antibacterial activity when compared to that of standards.

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