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Journal of Pharmacology and Toxicology
Year: 2007  |  Volume: 2  |  Issue: 3  |  Page No.: 248 - 255

Synthesis and Pharmacological Study of Some Novel Schiff Bases of 4-Hydroxy 6-Carboxhydrazino Benzothiophene Analogs

K.N. Venugopala, Gopal Krishna Rao and P.N. Sanjay Pai    

Abstract: A versatile method for the synthesis of novel schiff bases of 4-hydroxy 6-carboxhydrazino benzothiophene derivative was described. The title compounds were characterized on the basis of spectroscopic techniques and evaluated for their qualitative and quantitative antibacterial activity by agar cup plate method and micro titration method, respectively. From the biological activity it was possible to observe that some of the substituents on the phenyl ring of the benzothiophene analogs influenced the biological activity.

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