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Journal of Pharmacology and Toxicology
Year: 2007  |  Volume: 2  |  Issue: 2  |  Page No.: 200 - 204

The Immunostimulatory Effects of Ethanolic Extract of Cassia alata on Immune System of Albino Rats Dosed with Staphylococcus aureus (NCIB 8588)

M.K. Oladunmoye    

Abstract: The immunostimulatory effect of the ethanolic extract of Cassia alata was tested on Swiss albino rats infected with Staphylococcus aureus by evaluating the White Blood Cells (WBC), Packed Cell Volume and total differential WBC count. The rats were in 6 groups of 2 animals per cage. The first group was given the standard inoculum but not treated. The second group was given the standard inoculum and treated with the extract. The third group was given Cassia alata ethanolic extract only while the control was given normal saline. Increase in White Blood Count (WBC) from 5000 to 7600 mm3, decrease in Packed Cell Volume (PCV) from 51 to 21% and increase in neutrophil-lymphocyte ratio indicates active infection in the infected-untreated group. In the group treated with extract there was lower White Blood Count (WBC) of 5000 and 2900 mm3 before and during infection, respectively. Decrease in neutrophil-lymphocyte ratio indicates suppression of infection/inhibition of proliferation of Staphylococcus aureus infection. The group given extract only showed WBC, PCV, Neutrophil and Lymphocyte value of 5200 mm3, 45, 44 and 55% before infection; 2300 mm3. 32, 50 and 50% during infection and 3100 mm3, 32, 72 and 28% after infection, respectively. There is a boosting of the immune system as compared to the control. The result of the urinalysis showed a pH of 5, negative to glucose, Ascorbic acid, Ketone, Nitrite, Bilirubin, Protein and Blood, normal for Urobilinogen for all the groups before infection. The untreated rats showed a pH of 7 positive for nitrite and Bilirubin, negative for other parameters. The infected/untreated rats showed 6-8 pus cells/HPF, 2-4 casts/HPF, 6-8 crystals/HPF and 4-6 bacterial cells/HPF indicating active infection. The result of this study is significant for the development of Cassia alata to be utilized as an augment for the current antimicrobial therapy that is becoming less efficacious against Staphylococcus aureus.

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