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Journal of Pharmacology and Toxicology
Year: 2006  |  Volume: 1  |  Issue: 5  |  Page No.: 478 - 484

Protective Effects of Some Tropical Vegetables against CCl4 Induced Hepatic Damage

S.O. Salawu and A.A. Akindahunsi    

Abstract: In the present study, ethanolic extracts of some tropical vegetables were investigated for their hepatoprotective effect against CCl4 induced liver damage in rats. Carbon tetrachloride at a dose of 0.5 mL kg-1 body weight (b.w) produced liver damage in rats as manifested by the rise in the levels of ALT (IU L-1), AST (IU L-1) and total protein (g L-1) in the serum (40.60±3.50, 80.60±5.10, 73.20±1.87) and in the liver homogenate (1300.00±7.38, 1660.00±13.69, 250.00±7.51) compared to the control. The extracts at a dose of 250 and 500 mg kg-1 bw were administered to the CCl4 treated rats. The vegetables produced a significant hepatoprotective effect by decreasing the serum levels of ALT, AST and total protein in the range of 11.21±1.90-16.22±1.00, 29.00±2.70-48.00±2.10, 62.10±2.40-70.13±2.00 at a dose of 250 mg kg-1 and 13.00±1.20-21.00±1.30, 40.00.±2.5-59.00±2.20, 68.00±2.40-72.00±2.10 at a dose of 500 mg kg-1. Similar results were obtained for liver homogenate levels of ALT, AST and total protein with a decreasing values compared to the control; 900.00±3.05-1020.00±4.25, 1150.00±5.57-1530.00±4.99, 150.00±3.12-185.00±3.00 and 900.00±3.05-1030.00±8.80, 1400.00±6.95-1530.00±8.50, 165.00±5.50-210.00±4.41 at a dose of 250 and 500 mg kg-1 b.w respectively. Furthermore, the effect of the extracts on lipid peroxidation, measured as Malondialdehyde (MDA) was estimated on the liver homogenate. A significant hepatoprotective effect was also noticed with a decreased value of the MDA levels: 46.00±0.08-52.00±0.06 and 47.00±0.07-60.00±0.10 at a dose of 250 and 500 mg kg-1 bw respectively. It can be concluded that all the evaluated vegetables exhibit good hepatoprotective activities, though at varying degrees.

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