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Journal of Pharmacology and Toxicology
Year: 2006  |  Volume: 1  |  Issue: 3  |  Page No.: 289 - 292

Effects of Hypericum Perforatum L. and Matricaria Chamomilla L. Extracts on the Human Chromosomes

Mostafa Saadat    

Abstract: The cytogenetic effects of the Hypericum perforatum L. and Matricaria chamomilla L. extracts have been studied in cultured human lymphocytes. The extracts were prepared by perculation method using 70% ethanol as a solvent. The effects of hydroquinone and ethanol were also investigated as positive and negative controls, respectively. The cytogenetic abnormalities detected were dicentric chromosome, chromatid breaks and polyploidy. The Hypericum perforatum L. (at final concentration of 0.4 μg mL-1 hypercin) and Matricaria chamomilla L. (at final concentration of 50 μg mL-1 chamazulenel) extracts, significantly increased the frequency of abnormal metaphases (For extract of Hypericum perforatum L. OR = 6.04, 95% CI: 3.11-12.1; For extract of Matricaria chamomilla L. OR = 6.22, 95% CI: 3.21-12.2).

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