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Journal of Pharmacology and Toxicology
Year: 2006  |  Volume: 1  |  Issue: 3  |  Page No.: 278 - 283

The in vitro Antibacterial Activity of Methanol and Ethanol Extracts of Carica papaya Flowers and Mangifera indica Leaves

Z.A. Zakaria, A.M. Mat Jais, M.R. Sulaiman, S.S.P. Mohamed Isa and S. Riffin    

Abstract: The present study was carried out to evaluate the possible antibacterial activity of methanol and ethanol extracts of Mangifera indica leaves and Carica papaya flowers using the in vitro disc diffusion methods. The sterilized blank discs (6 mm diameter) was impregnated with 20 μL of the respective extract in the concentrations of 12.5, 25, 50 and 100% and tested against Corneybacterium diptheriae, Staphylococcus aureus, Streptococcus pneumoniae, Salmonella typhi, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Proteus vulgaris. The methanol and ethanol extracts of M. indica were effective against C. diptheriae, S. aureus, S. typhi and P. aeruginosa, with the latter producing slightly bigger inhibitory zone against some of the bacteria when compared to the former. The methanol and ethanol extracts of C. papaya were effective only against S. aureus and S. pneumoniae, with the latter also effective against C. diptheriae. As a conclusion, the present study demonstrated the potential of M. indica leaves and C. papaya flowers as antibacterial agents against some of the bacteria tested and thus may provide the basis for the isolation of bioactive compounds with antibacterial activity from the respective plant leaves or flowers.

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