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Research Journal of Parasitology
Year: 2013  |  Volume: 8  |  Issue: 2  |  Page No.: 55 - 63

Efficacy of Combined Therapy of Artemether and Somatostatin in Heptic Hydroxyproline in Experimental Murine Schistosomiasis Mansoni

Mai A. Hegazi and Madiha Mahmoud    

Abstract: The study aimed to examine the effect of combined therapy of artemether (ART) and somatostatin (SOM) on liver fibrosis in experimentally infected mice with Schistosoma mansoni. Infected mice were investigated following administration of either SOM, ART or their combination. Each regimen was administered at 2, 5 and 13 weeks post-infection (PI) to separate groups which were respectively sacrificed at 5, 8 and 16 weeks PI. Liver fibrosis was assessed by chemical measurement of heptic hydroxyproline as a marker of collagen content in liver. The extent of infection was monitored by liver egg load. The results were interpreted in comparison with corresponding ones in untreated S. mansoni-infected mice and age-matched normal control mice. Combined treated group showed the highest significant lower mean of hepatic hydroxyproline content than the infected control in 2, 5 and 13 weeks PI (793.41±64.91, 1010.87±75.67 and 1021.42±135.60) respectively in comparison to control group. ART administration group attained nearby significant lower measures as that of combined therapy group in the three successive periods of the experiment (893.57±31.83, 1035.91±42.24, 1228.34±26.52) in comparison to control group. SOM treated group attained significant lower hydroxyproline content in only 5 weeks PI (1145.30±80.91) and 13 weeks PI (1154.53±60.84). The study concluded that the combined therapy seemed not to be more effective than ART alone. By implication SOM therapy does not appear to have an additive effect on ART treatment.

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