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Research Journal of Parasitology
Year: 2009  |  Volume: 4  |  Issue: 1  |  Page No.: 12 - 21

Effects of Clerodendrum violaceum Leaf Extract on Some Liver Function Indices in P. berghei-Infected Mice

J.O. Adebayo, A.H. Zailani and E.A. Balogun    

Abstract: The effects of daily oral administration of ethanolic extract of Clerodendrum violaceum leaves (13 mg kg-1 body weight) for 5 days on some liver function indices of Plasmodium berghei-infected mice were investigated. The evaluations were done on days 3, 8 and 14 post-infection. The indices studied include serum albumin, globulin, total protein, total bilirubin and conjugated bilirubin concentrations with the specific activities of Glutamate Pyruvate Transaminase (GPT), Glutamate Oxaloacetate Transaminase (GOT), Alkaline Phosphatase (ALP) and γ-Glutamyl Transferase (GGT) in the liver and serum. Treatment of infected mice with extract was able to significantly (p<0.05) ameliorate the alterations in all the parameters observed in infected untreated mice, comparing favourably with chloroquine treatment. Administration of extract to uninfected mice showed no significant effect (p>0.05) on the parameters studied both in the serum and liver compared to the uninfected untreated control, except that it significantly increased (p<0.05) liver GPT activity. The results of this study suggest that the ethanolic extract of Clerodendrum violaceum leaves is able to considerably reverse the alterations caused by malaria infection in all parameters studied and is relatively non-toxic. Further studies on Clerodendrum violaceum as a source of antimalarial remedy are indicated on the basis of these results.

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