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Journal of Medical Sciences
Year: 2020  |  Volume: 20  |  Issue: 1  |  Page No.: 18 - 23

Relationship Between Interleukin-10, Cholesterol and Blood Glucose Levels in Geohelminth Positive Adolescents and Adults

Nurhayati, Nuzulia Irawati, Eryati Darwin and Nur Indrawaty Lipoeto    

Abstract: Background and Objective: Geohelminth is a common cause of chronic infections in humans. Worm infections have been shown to have a protective effect against some diseases. The effect is related to the ability of the worm to modulate the host immune response through Th2. The aim of study was to investigate the correlation between IL-10 levels and blood cholesterol and glucose in geohelminth positive human subjects with mature immune systems. Materials and Methods: Stool examination for geohelminth was done by direct method using iodine and by Kato Katz method. IL-10 levels were measured by indirect enzyme-linked immunosorbent assays (ELISA) method. Total plasma cholesterol levels were examined by CHOD-PAP method and fasting blood glucose was measured using hexokinase method. Results: All subjects infected with geohelminth classified as a mild infection. There was no correlation between IL-10 levels and EC/GC (p>0.05) but there was a negative correlation between IL-10 levels with TC levels (p<0.01) and between IL-10 levels and FBG levels (p<0.01). Conclusion: A negative correlation between IL-10, TC and FBG further strengthens support for the role of Th2 especially IL-10 to low cholesterol and blood glucose levels in geohelminth infections.

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