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Journal of Medical Sciences
Year: 2017  |  Volume: 17  |  Issue: 2  |  Page No.: 75 - 80

Pharmacological Changes after Black Scorpion Heterometrus fastigiousus Couzijn Envenomation in Mice

Mukesh Kumar Chaubey    

Abstract: Inspite of the extensive researches regarding the pharmacological consequences of scorpion envenomation, toxic effect of Asian black scorpion, Heterometrus fastigiousus (H. fastigiousus) Couzijn (Family: Scorpionidae) venom and mechanism by which envenomation exerts its effects in the victim have not yet been clearly known. The present study was aimed to investigate the effects of H. fastigiousus venom in albino mice in order to understand the mechanism of toxicity. Venom was obtained by electrical stimulation and its toxicity was determined in albino mice by subcutaneous envenomation. Effects on different biomolecules and enzymes in blood serum of albino mice were determined after experimental envenomation with sub-lethal doses of H. fastigiousus venom. Student’s t-test and F-test was used for analysis of data. The LD50 of H. fastigiousus venom was 18.6 mg kg–1 b.wt. Increased levels of serum glucose, pyruvic acid, lactic acid and creatinine were observed after H. fastigiousus envenomation. Elevated levels of circulating lactic dehydrogenase and creatine kinase were observed. Decrease in glycogen content was observed in the liver and gastrocnemius muscle tissue after experimental envenomation with sub-lethal doses of H. fastigiousus venom. This study helps to understand the mechanism of toxicity of Asian black scorpion, H. fastigiousus venom. This will help the pharmacologists to design drugs for the treatment of accidental H. fastigiousus envenomation.

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