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Journal of Medical Sciences
Year: 2015  |  Volume: 15  |  Issue: 2  |  Page No.: 87 - 93

Effect of Egeriaradiata (Clam) Extract on Biochemical Parameters of Albino Wistar Rats

Archibong Nsa Archibong, Akwari AdaAk, Ofem Effiong Ofem, Irene Okon Bassey, Samuel Usoh Ukweni and Asim Ekaha Eno    

Abstract: Edible seafood (Clam) are important nutritive diet because they contain great quantities of protein and essential fatty acid (alpha linolenic (Omega 3), linoleic (omega-6) and oleic (omega 9) fatty acid) etc which are essential for healthy living, therefore this research seeks to investigate the effect of this dietary seafood on biochemical parameters of albino Wister rats. Fifteen albino Wister rats weighing between 200-250 g were assigned into 3 groups of 5 rats each in metabolic cages and were given rat feed and drinking water ad libitum. Two test doses (low dose-7.0 mg mL–1 and high dose-52 mg mL–1) base on previously obtained LD50 were selected and administered to two groups of rats orally, while the third group of rats served as the control, n = 5. At the end of six weeks blood samples were obtained from all the rats via cardiac puncture for the analysis of the various biochemical parameters. Both the low and high doses of the extract treated groups produced significant increase in total protein (p<0.001), globulin (p<0.001) and HDLC (p<0.001) compared with control. The k (p<0.001), Hco (p<0.01) and Ca (p<0.001) ion concentrations were also increased significantly in the extract treated groups compared with the control. The extract treated groups had significantly reduced ALT (p<0.001), ALP (p<0.001), Na+ (p<0.001) and Cl‾ (p<0.001) compared with control. Also TC (p<0.001), TG (p<0.001) and LDL (p<0.001) were significantly reduced in the extract treated groups. Consumption of dietary clam is of great benefit, because it protect the hepatocytes and also prevents one from being predispose to atherogenesisor dyslipidaemic conditions.

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