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Journal of Medical Sciences
Year: 2014  |  Volume: 14  |  Issue: 4  |  Page No.: 192 - 200

25-Hydroxyvitamin D3 Level in Patients with Chronic Viral Hepatitis B

Mohammed Amin Mohammed, Nesreen Moustafa Omar, Amany H. Mansour, Sherin Mohamed Abd El-Aziz and Gamal Othman    

Abstract: Vitamin D is an important immune modulator that has an emerging role in inflammatory and metabolic liver diseases. An association has been established between low levels of vitamin D and several adverse health outcomes including upper respiratory and enteric infections, viral hepatitis and HIV infections. It exerts protective effects during infections by up-regulating the expression of cathelicidin and β-defensin 2 in phagocytes and epithelial cells. Thus, vitamin D appears to have systemic antimicrobial effects that may be crucial in a variety of both acute and chronic illnesses. In the current study, 25-hydroxyvitamin D3 (25-OHD3) levels were compared among 75 patients with chronic hepatitis B virus infection (Group I), sixty naturally immunized individuals (Group II) and another sixty age and sex-matched healthy controls. Routine biochemical parameters like hepatitis markers, hepatitis B virus serology, hepatitis B virus DNA, 25-OHD3 and Parathormone levels were measured. Patients in group I had a significantly lower 25-OHD level compared with group II and controls (13.9±4.93 vs. 22.1±6.14 and 23.15±8.28 ng mL-1, respectively p<0.001). In contrast, patients in group I had a higher parathyroid hormone level compared with group II and control group (103.14±24.5 vs. 75.14±23.4 and 74.1±20.15 pg mL-1, respectively p<0.001). Also, 25-OHD levels were inversely correlated with hepatitis B virus DNA levels. The observed diminished 25-OHD levels in patients infected with hepatitis B virus may be an indicator of the viral replication status and portends a poor prognosis.

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