Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Journal of Medical Sciences
Year: 2013  |  Volume: 13  |  Issue: 8  |  Page No.: 814 - 818

Formulation and Evaluation of Standardised Withania somnifera Leaf Extract Loaded Transdermal Gel

Monika Joon and Munish Garg    

Abstract: Several technological advances have been made in the recent years to overcome skin barrier properties and to enhance drug penetration. In this regard, transdermal drug delivery system provides a suitable solution of the problems associated with conventional routes of drug administration. In the present study, Withania somnifera leaf extract loaded proniosomal gel was prepared and evaluated for better delivery and improved anti-inflammatory property. The formulated gel was characterized for vesicle physical analysis, entrapment efficiency and in vitro release study. The method used for preparation of proniosomal gel resulted in higher drug entrapment value of 87.2%. Scanning electron microscopy analysis showed that the surface of the particles was smooth. The formulations showed prolonged in vitro drug release of 60.8% over a period of 24 h and significant anti-inflammatory response. From this study, it is concluded that proniosomes are very stable and promising delivery system for Withania somnifera leaf extract.

Cited References   |    Fulltext    |   Related Articles   |   Back
 
 
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility