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Journal of Medical Sciences
Year: 2013  |  Volume: 13  |  Issue: 1  |  Page No.: 67 - 71

Effect of Soursop (Annona muricata L.) Fruit Extract on Sperm Toxicity Induced by Caffeine in Albino Rats

U.B. Ekaluo, E.V. Ikpeme, Y.B. Ibiang and F.O. Omordia    

Abstract: Extracts of Annona spp. have been used for several medicinal purposes such as the management of diabetes and its complications, also as antioxidant and antimutagenic agents. There have been attempts to attenuate toxic effects using medicinal plants. Hence, the mitigating effect of soursop (A. muricata) fruit extract on sperm toxicity induced by caffeine was accessed on the weight of testes and epididymes, epididymal sperm count, motility, viability, semen pH and sperm head abnormality in albino rats as a model. The male rats were divided into five groups of six rats each. The rats were administered with treatments of caffeine and Soursop Fruit Extract (SFE) for 65 days. In conclusion, SFE mitigated the caffeine-induced toxicity on weight of testes and epididymes, sperm motility, sperm count and sperm head abnormality in the mammalian model.

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