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Journal of Medical Sciences
Year: 2012  |  Volume: 12  |  Issue: 7  |  Page No.: 229 - 233

Oxidant versus Antioxidant Activity in Malaria: Role of Nutritional Therapy

O.I. Iribhogbe, E.O. Agbaje, I.A. Oreagba, O.O. Aina and A.D. Ota    

Abstract: Micronutrients are known to have antioxidant activity; however, its role in plasmodial infection is still not clearly defined. The present study involves an in vivo evaluation of the role of some selected antioxidant micronutrients in the therapeutics of malaria. In this study, rodent malaria model using Plasmodium berghei NK-65 strain (chloroquine sensitive) was used. Fourty five mice of either sex weighing 20.05±0.02 g were used for the study. Fourty mice were inoculated intraperitoneally with 1x107 million Plasmodium berghei infected erythrocyte and were administered with 0.2 mL of distilled water, 0.2 mL of vehicle; Tween 80 (control and vehicle group), chloroquine 25 mg kg-1 and artesunate 4 mg kg-1 (standard drug group), vitamin A 60 mg kg-1, vitamin E 100 mg kg-1, selenium 1 mg kg-1, zinc 100 mg kg-1 (test group F, G, H and I, respectively) 72 h post inoculation. Antioxidant micronutrients demonstrated significant (p<0.05) chemosuppressive activity when compared with negative control during the 4 day curative test. Mean parasitemia was significantly reduced (p<0.05) in the micronutrient treated groups after the 4 day curative test when compared with negative control. This however, was also significant between micronutrient treated groups (F = 17.88; p = <0.05). Catalase and glutathione peroxidase activity was significantly (p<0.05) higher in the vitamin A, E, selenium and zinc treated groups, respectively when compared to apparently healthy uninfected control. Conclusively, antioxidant micronutrients have antimalarial activity and may be of benefit in malaria therapeutics.

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