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Journal of Medical Sciences
Year: 2012  |  Volume: 12  |  Issue: 6  |  Page No.: 193 - 197

Expression of CDK6 in Salivary Gland Tumors

Soheil Pardis, Azadeh Andisheh Tadbir, Zohreh Jafari Ashkavandi, Ali Dehghani Najvani, Mohammad Javad Ashraf and Hoda Ranjbaran    

Abstract: To investigate the expression of CDK6 in salivary gland tumors. In this study, 59 samples of salivary gland tumors from Khalili Hospital pathology archive, including 19 cases of pleomorphic Adenoma, 14 cases of Mucoepidermoid Carcinoma and 19 cases of Adenoid Cystic Carcinoma, as well as 10 cases of normal salivary gland tissue, were reviewed by Immunohistochemistry (IHC) for CDK6 staining. CDK6 expression in normal salivary gland was limited to the cytoplasm of ductal cells, but in tumoral tissues was both nuclear and cytoplasmic. Mean percentage of CDK6 staining in the tumoral group (17.38±21.25) was significantly higher than the normal group (1.1±0.99). So, we recognized a higher expression of this marker in tumoral lesions than in normal tissues (p = 0.021). But there wasn’t any statistically significant difference between expression of CDK6 in different types of tumors (p = 0.2). This study demonstrated that over expression of nuclear CDK6 and the dysregulation of PRb pathway play a role in the oncogenesis of salivary gland tumors.

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