Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Journal of Medical Sciences
Year: 2009  |  Volume: 9  |  Issue: 1  |  Page No.: 1 - 9

Combined Treatment of Rutin and Vitamin C Improves the Antioxidant Status in Streptozotocin-Induced Diabetic Rats

Mohammed A. Alsaif    

Abstract: The aim of the present study is to determine if a combination of rutin (vitamin-P) and vitamin C has any advantage on antioxidant status in streptozotocin (STZ)-induced diabetes in rats. Oral administration on rutin (100 mg kg-1), vitamin C (200 mg day-1) and their combination (50 and 100 mg kg-1) for 5 weeks on the levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), glucose, insulin, Total Cholesterol (TC) and triglycerides (TG) in normal and STZ-induced diabetic rats were evaluated. Reduced glutathione (GSH), Malondialdehyde (MDA) and superoxide dismutase (SOD) concentrations were estimated in liver. Histopathological changes were screened in liver. Body weight significantly (p<0.001) drops although liver and kidney weights were increased in diabetic rats. Hepatic enzymes (AST, ALT and ALP), cytokines (TNF-α and IL-6) and lipids (TC and TG) were significantly elevated in diabetic rats. Treatments with rutin and vitamin C significantly lowered the elevated values in diabetic rats while it found higher in combined treated group. Liver MDA increased, GSH and SOD levels decreased significantly (p<0.001) in diabetic rats. The treatment with rutin and vitamin C lowered MDA and increased the antioxidant levels to near control values. The results verify the presence of oxidative stress in diabetes and suggest beneficial effects of rutin and vitamin C combinations in combating the oxidative stress in this disease.

Cited References   |    Fulltext    |   Related Articles   |   Back
  Related Articles

Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility