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Journal of Medical Sciences
Year: 2008  |  Volume: 8  |  Issue: 8  |  Page No.: 691 - 698

Lipid Profile and Lipid Peroxidation among Ghanaian Pregnancy-Induced Hypertensives

L. Ahenkorah, W.K. B.A. Owiredu, E. F. Laing, N. Amidu and C. A. Turpin    

Abstract: This study was aimed at investigating oxidative stress among Ghanaian women with Pregnancy-Induced Hypertension (PIH). One hundred Pregnancy-Induced Hypertension women: Thirty with preeclampsia, seventy with gestational hypertension and fifty normotensive pregnant women (controls) in the second half of pregnancy were recruited for this study. There was a significant increase in triglycerides and LDL-cholesterol in the subject groups compared to the control. Malondialdehyde (MDA), the lipid peroxidation marker among the PIH subjects was significantly increased as compared to the normotensive pregnant women (controls). A significant positive correlation between MDA and blood pressure (Systolic and Diastolic blood pressure) was also observed. This study clearly indicates that Ghanaian women presenting with PIH are very prone to dyslipidemia as well as lipid peroxidation, this might in part explain the oxidative stress and endothelial vascular dysfunction observed in these group of women.

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