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Journal of Medical Sciences
Year: 2008  |  Volume: 8  |  Issue: 6  |  Page No.: 574 - 578

Vaginal Colonization of Group B Streptococci During Late Pregnancy in Southeast of Iran: Incidence, Serotype Distribution and Susceptibility to Antibiotics

S. Mansouri, E. Ghasami and N. Shahabi Najad    

Abstract: The objective of present study was to determine reliable data on vaginal carriage, serotype distribution and antibacterial susceptibility of Streptococcus agalactiae, Group B streptococcus (GBS) in pregnant women in southeast of Iran. Vaginal swab cultures for GBS were obtained from 602 pregnant women at childbirth. Susceptibility of the isolates to penicillin, ampicillin, clindamycin and erythromycin were determined by standard agar dilution method. Isolates were classified according to their capsular polysaccharide types. GBS was isolated from 55 pregnant women (9.1%). All isolates were sensitive to penicillin and ampicillin [Minimum Inhibitory concentration (MIC) range of 0.03-16 μg mL-1 and ≤ 0.03-1 μg mL-1, respectively). Erythromycin and clindamycin resistance were seen in 10.9% (MIC range ≤ 0.03-16 μg mL-1) and 25.4% (MIC range ≤ 0.03-32 μg mL-1) of the isolates, respectively. Serotype III (41.8%), Ib (25.45%) and II were the most frequently isolated serotypes (14.54%). Group IV was not detected and 14.54% of the isolates were non type-able. No correlation was found between GBS colonization and demographic factors of age, parity, history of abortion or ruptured membrane and vaginal signs or symptoms. In conclusion the rate of GBS colonization is low in this area, but serotype III, which is mostly involved in invasive disease is the predominant serotype. Routine maternal screening should be performed to prevent group B streptococcal disease in neonates in this district. Susceptibility to the isolates to clindamycin and erythromycin should be checked in the penicillin-allergic patients, to avoid treatment failure.

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