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Journal of Medical Sciences

Year: 2008  |  Volume: 8  |  Issue: 6  |  Page No.: 564 - 568

The Investigation of p53 and Ki-67 Gene Mutations in Relation with Helicobacter pylori Infection in Patients with Gastric Cancer

J. Rezaii, 1H. Ashegh, M. Hasibi, M. Behzadi, F. Khodadadi and M. Heidarali


The aim of this study was to evaluate the role of Helicobacter pylori infection in relation with p53 and Ki-67 mutations in a case-control study in Iran, an endemic region for H. pylori infection. Sixty nine cases with gastric cancer and 96 cancer-free control subjects with either gastric ulcer or chronic gastritis were studied. Age, sex, H. pylori serology and presence of p53 and Ki-67 mutations were determined for all subjects. There was no significant difference between the groups for age (p = 0.17) but the groups were significantly different regarding sex (p = 0.004). The frequency of H. pylori seropositivity and presence of p53 mutation were more common in case group (p<0.001 and p<0.001) while the difference between groups was not statistically significant for presence of Ki-67 mutation (p = 0.61). After multivariate analysis the effect of p53 mutation (p<0.001, adjusted OR = 126.56, 95% CI: 28.58-560.40) and Ki-67 mutation (p = 0.02, adjusted OR = 0.21, 95% CI: 0.05-0.84) remained significant. H. pylori seropositivity lost its role in the presence of gastric cancer after multivariate analysis and the presence of p53 and Ki-67 were independent affecting factors for gastric cancer even in an endemic region for H. pylori such as Iran.

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