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Journal of Medical Sciences
Year: 2008  |  Volume: 8  |  Issue: 4  |  Page No.: 390 - 394

Effects of Dietary Cholesterol on Some Serum Enzymes

O.M. Oluba, O. Adeyemi, G.C. Ojieh, K.E. Adebisi, I.O. Isiosio and C.O. Aboluwoye    

Abstract: The activities of serum enzymes were investigated in rats feeding on 5 and 10% cholesterol. Rat were subjected to feeding over a period of seven weeks on formulated diets containing no cholesterol supplement, 5 and 10% cholesterol respectively. Serum cholesterol, triglycerides, gamma-glutamyl transpeptidase (GGT), lactate dehydrogenase (LDH), alanine transaminase (AST) and Aspartate Transaminase (AST) of rat placed on the formulated diets were measured every week for seven weeks. Relative to the control, the serum parameters studied increased significantly (p<0.05) in the test rats. In contrast, the body weight of rats was significantly lower than that of the control rats (p<0.05). It eas considered that consumption of the cholesterol based diet may not lead to increase in body weight. However, it could increase the risk of heart related diseases.

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