Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Journal of Medical Sciences
Year: 2008  |  Volume: 8  |  Issue: 3  |  Page No.: 287 - 292

Alteration of Serum Levels of Interlukin 1 and Tumor Necrosis Factor in Depression Independentof Treatment or Overdose of Tricyclic Antidepressants

Haleh Talaie, Abdolkarim Pajoumand, Reyhaneh Panahandeh, Behjat Barari, Maryam Baeeri and Mohammad Abdollahi    

Abstract: The aim of this study was to evaluate the status of serum IL-1b and TNF-α in depressed patients who treated or non-treated or poisoned with tricyclic antidepressants (TCAs) in comparison to healthy subjects. In this prospective comparative study, patients were selected from those admitted at Loghman-Hakim Hospital from August 2007 to January 2008. Serum level of IL-1b and TNF-α were compared among group of subjects (10 in each) of healthy subjects, TCA-poisoned patients, TCA-treated depressed patients and non-treated depressed patients. Demographic and clinical data were collected by a questioner filled out by a trained practitioner in daily clinical management. Blood was tested for liver function, blood cells, electrocardiography and arterial blood gases. Complete blood analysis and demographic data did now show significant change between groups. IL-1b level was higher among females. The group of depressed patients non-treated with TCAs showed higher serum levels of IL-1b and TNF-α than other groups. No significant difference was observed in IL-1b and TNF-α values among healthy control, depressed TCA-treated and TCA-poisoned groups. It is concluded that depression and gender may influence the production of cytokines while neither TCAs treatment nor its overdose affect IL-1b and TNF-α.

Cited References   |    Fulltext    |   Related Articles   |   Back
 
 
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility