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Journal of Medical Sciences
Year: 2007  |  Volume: 7  |  Issue: 6  |  Page No.: 977 - 983

Antihypertensive and Some Biochemical Effects of Hydrochlorothiazide and Furosemide in Some Nigerians

G.B.S. Iyalomhe, E.K.I. Omogbai and R.I. Ozolua    

Abstract: The objective of this prospective, randomised, open, single-centre study was, therefore, to determine the antihypertensive and biochemical effects of 25 mg oral hydrochlorothiazide and 40 mg oral furosemide given once daily for 21 days to 40 patients with mild to moderate uncomplicated essential hypertension aged between 32 and 80 years and 40 age and sex-matched normotensive controls while on their usual diet. Urine volume, systolic and diastolic BP evaluated as Mean Arterial Pressure (MAP) as well as urine and serum sodium (Na+), potassium (K+) and chloride (Cl) were assessed before and during treatment. Both drugs significantly increased diuresis (p< 0.0001); lowered MAP (p< 0.0001) and increased urine K+ (p< 0.001) in the hypertensive subjects compared to controls. It is concluded that once daily 25 mg of hydrochlorothiazide and 40 mg of furosemide are effective in lowering BP as monotheraphy in Nigerians with mild to moderate hypertension and they are associated with some adverse biochemical effects including K+ depletion.

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