Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Journal of Medical Sciences
Year: 2007  |  Volume: 7  |  Issue: 4  |  Page No.: 682 - 685

Angiotensin I-Converting Enzyme Gene Polymorphism in Type 2 Diabetic Patients with Nephropathy

Mesbah Uddin, Mashiul Azam, Nizamudddin Chowdhury and Sharif Akhteruzzaman    

Abstract: Angiotensin-I Converting Enzyme (ACE), a major component of the Rennin-Angiotensin System (RAS) regulates the renal hemodymamics of our body. An insertion/deletion (I/D) polymorphism of ACE gene has been implicated in kidney disease, hypertension and cardiac function. In the present study, we investigated I/D polymorphism of ACE gene in 125 subjects of both sexes, consisting of 66 normal controls and 59 type 2 diabetic patients with nephropathy. The allele and genotype frequency were significantly different between the patients with diabetic nephropathy and control groups (p<0.001). In the nephropathic patients, ID and DD genotypes were present in 37.2 and 40.6% of patients respectively as compared to 42.4 and 21.2% in those of control groups. The D allele was present in 55.5% of the nephropathic patients and 44.4% of the normal controls. Therefore, percentage of DD genotype and D allele was significantly higher in nephropathic patients compared to normal controls.

Cited References   |    Fulltext    |   Related Articles   |   Back
 
 
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility