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Journal of Medical Sciences
Year: 2007  |  Volume: 7  |  Issue: 4  |  Page No.: 536 - 543

The Assessment of a Fruit Extract (Sechium Edule) on the Bioavailability of Radiopharmaceutical Sodium Pertechnetate in Wistar Rats with Diabetes Induced by Streptozotocin

G.F. Dire, P.R.A. Siqueira, R.M. Duarte, M.C.L. Almeida, J.S. Rodrigues, J.C.S. Oliveira, S.D.D. Vasconcelos, M.L. Fernandes and M. Bernardo-Filho    

Abstract: We evaluated the influence of a chayotte(Sechium edule) extract (macerated) and diabetes status on the bioavailability of 99mTcO4Na. In this study, in the biodistribution analysis, the 99mTcO4Na (0.3 mL) was administrated into female Wistar rats (diabetes and no diabetes induced) which had drunk or not the extract (macerated) for 7 days. After 10 min, animals were sacrificed, the organs were isolated, the radioactivity determined in a well counter and the percentages of radioactivity (%ATI) in the organs was calculated. The analysis of the results has indicated an increase in the %ATI in the group treated with chayotte extract (0.0040±0.0010 to 0.0060±0.0010). In the diabetes group it was observed a decreased in the %ATI (0.0040±0.0010 to 0.0030±0.0010) as well as in the diabetes group treated with chayotte extract (0.0040±0.0010 to 0.0020±0.0003). Due to the %ATI in the muscle it was verified that there was an increase of the %ATI in the group treated with chayotte extract (0.0090±0.0040 to 0.0230±0.0070) and in the diabetes group treated with chayotte (0.0090±0.0040 to 0.0180±0.0230). It was observed a difference between the group treated with chayotte to the diabetes group (0.0230±0.0070 to 0.009±0.0040) and between the diabetes group to the diabetes group treated with chayotte extract (0.0090±0.0040 to 0.0180±0.0230). Related to %ATI in the spleen by the light of the results it was detect a difference in the uptake of sodium pertechnetate between the group treated with chayotte extract to the diabetes group treated with the referred extract (0.0290±0.0013 to 0.0480±0.0160). Due to the biodistribution it was related that an extract of eggplant was capable of altering the bioavailability of 99mTcO4Na different of a cauliflower extract which has not been able to alter it. It is possible to suggest that some components of chayotte extracts present an oxidant power able to alter the biodistribution of 99mTcO4Na, as a tip, we speculate that the referred extract when metabolized in the liver may produce reactive metabolites with oxidant properties linked to the stress which is generated by diabetic status, this fact could justify by the increase of %ATI in the brain, muscle and spleen which probably may be due to the producing of AGEs in diabetes status.

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