Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Journal of Medical Sciences
Year: 2007  |  Volume: 7  |  Issue: 8  |  Page No.: 1225 - 1238

Chloroquine-Induced Retinopathy in the Rat. Immunohistochemical and Ultrastructural Study

Dina H. Abdel Kader, Safinaz Salah El Din Sayed and Tarek A. El-Ghamrawy    

Abstract: The aim of this study is to detect the changes induced by chloroquine administration on the retina of rat using immunohistochemical and ultrastructural methods. Thirty-two male adult albino rats were used, divided into four groups (n = 8 each): 1, 2, 3 and 4, further subdivided into control (n = 2) and experimental (n = 6) subgroups. The experimental subgroups received chloroquine for one, two, three and four months, respectively. The eye balls were processed for light microscopic, immunohistochemical and ultrastructural evaluation, followed by morphometric assessment and statistical analysis. Examination of haematoxylin and eosin stained sections showed significant progressive thinning of Outer Reticular Layer (ORL) and Inner Nuclear Layer (INL) associated with decreased Ganglion Cell (GC) count. Positive Amyloid Precursor Protein (APP) immunostaining was first noticed in the GCs. Later, it was observed in the INL as well. Ultrastructural examination revealed cytoplasmic electron-dense membranous inclusion bodies in the ganglion, horizontal, amacrine and bipolar cells. The photoreceptors were involved on prolonged duration of administration.

Cited References   |    Fulltext    |   Related Articles   |   Back
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility