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Journal of Medical Sciences
Year: 2006  |  Volume: 6  |  Issue: 6  |  Page No.: 999 - 1002

Comparative Cytotoxicity Study of Six Bioactive Lectins Purified from Pondweed (Potamogeton nodosus Poir) Rootstock on Brine Shrimp

F. Pervin, M.M. Hossain, S. Khatun, S.P. Siddique, K.A. Salam, M.R. Karim and N. Absar    

Abstract: Six bioactive lectins were purified from the rootstock of Pondweeds (Potamogeton nodosus Poir) by conventional chromatographic methods. They showed cytotoxic effect in brine shrimp (Artemia salina L.) lethality bioassay. The LD-50 values of PNL-1, PNL-2, PNL-3, PNL-4, PNL-5 and PNL-6 were found to be 10.76, 7.03, 17.25, 10.52, 19.60 and 20.1 μg mL-1, respectively which implied that they have significant uses specially of PNL-2. Experimental results revealed that PNL-2 and PNL-4 were more cytotoxic than other lectins.

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