Serum Cholinesterase Level Reduction in Pesticide Factory Workers
In this study the sampling from 63 subjects was carried out for two sessions in days 1 and 90. Cholinesterase determination was performed with butyrylthiocholine substrate and enzymatic test was done using kinetic techniques. The mean serum cholinesterase level in phase 1 was 9569±2496 IU L-1 and in second phase the activity of cholinesterase was 7970±2067 IU L-1. This drop in cholinesterase level statistically was meaningful (paired t-test, mean = 1599, 95% CI = 1140-2058, p<0.001). ALT increase in second phase compared to first phase statistically was meaningful (Paired t-test, mean = -7.9, 95% CI = -10.9 -4.9, p<0.001). In this study eight subjects (12.7%) had more than 35% reduction in cholinesterase activity. In regard to reduction in cholinesterase activity of 17 workers which include 27% of working personals in a three months period it seems logical to set a program to have a routine check on the cholinesterase activity in working personal engaging in such occupations.
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