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Journal of Medical Sciences
Year: 2005  |  Volume: 5  |  Issue: 2  |  Page No.: 89 - 94

Effect of Heat Stress, Hypoxia and Hypoxia-hyperoxia on Free Radical Production in mice Mus musculus

A.S. Haffor and A. M. Al-Johany    

Abstract: The purpose of this study was to examine the effects of heat stress, hypoxia and hypoxia-hyperoxia on Free Radicals (FR) production in mice. Three experimental groups were exposed to three environmental conditions namely; heat stress (35-38°C); hypoxia (12-15% O2) and the third group underwent hypoxia (12-15% O2) followed by hyperoxia (100% O2). In comparison with control group, mean FR production increased significantly (p<0.05) by 44.89% in the heat stress group, 26.13% in the hypoxia group and by 77% in the hypoxia-hyperoxia group. The partial correlation coefficient (r = 0.81), controlling for control group, for the FR induced by heat stress on FR caused by hypoxia was significant (p<0.05) with regression coefficient of R2 = 0.75 which was also significant (p<0.05). These findings indicated that FR production is related to environmental stress induced by heat stress, reductive stress (hypoxia) and oxidative stress (hyperoxia). Heat stress has common effects with hypoxia on FR production. The effect of hyperoxia is increased if tissue ischemia presents prior exposure to oxidative stress exposure.

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