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Journal of Medical Sciences
Year: 2005  |  Volume: 5  |  Issue: 4  |  Page No.: 316 - 319

Screening 469 Escherichia coli Isolates Form South East of Iran for Tellurite Resistance Phenotype

Shahla Mansouri and Seyd Mohammad Nayebeeaghaei    

Abstract: Minimum Inhibitory Concentration (MIC) of tellurite was determined for 469 samples of Escherichia coli isolated from clinical samples in human (urinary tract infection, normal fecal flora), or poultry skin using standard agar dilution method. About half of the isolates (47.1%) had MIC of ≤1 μg mL-1 after 24 h of incubation at 35°C. Many of the bacteria that were cultured with low concentrations of potassium tellurite, ≤ 5 μg mL-1, overcome the toxicity of this heavy metal when they were re-incubated for the next 24 h. The MIC for these isolates was increased, so that the difference between the MIC after 24 and 48 h of incubation became significant (p≤0.0026). In medium containing ≥10 μg mL-1 of potassium tellurite, the bacteria formed typical black colonies. No statistically significant difference was found between the MIC of bacteria that where isolated from human, but higher rate of resistance was found for the Poultry skin samples and 25% of these isolates had MIC of ≥160 μg mL-1. Although for nearly half of the isolates potassium tellurite was toxic at low concentration (≤1 μg mL-1), higher MIC was observed for the rest of isolates (10-400 μg mL-1) and is an indication of the widespread resistance to potassium tellurite in E. coli in this region.

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