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Journal of Medical Sciences
Year: 2005  |  Volume: 5  |  Issue: 3  |  Page No.: 159 - 162

Comparative Study of the in vivo Response of Malaria Parasites to Chloroquine among the Urban and Rural Dwellers in Sokoto State, Nigeria

E.U. Etuk    

Abstract: The in vivo response of malaria parasites to chloroquine among the urban and rural dwellers in Sokoto state, Nigeria has been studied. A total of seventy-eight patients with acute uncomplicated malaria were selected for the study from two distinct centres representing the urban and rural dwellers of the state. All the treated cases from the rural centre (Umaruma) responded well; both the clinical features of the disease and the parasites in the blood cleared within three days of initiating treatment and there was no relapse after twenty-one days follow up. But 19.8% (5) of the patients from the urban centre showed resistance at R1 level to chloroquine. This study therefore concluded that, chloroquine is more effective for the treatment of malaria in the rural than the urban dwellers possibly because of the rampant abuse of the drug by the later group.

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