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Journal of Medical Sciences
Year: 2003  |  Volume: 3  |  Issue: 1  |  Page No.: 87 - 98

Antioxidant Activity of Algal Extracts on Lipid Peroxidation

Ahmed M. Aboul-Enein, Farouk K. El Baz, Gamal S. El-Baroty, A.M. Youssef and Hanaa H. Abd El-Baky    

Abstract: The antioxidant of seven algal extracts was evaluated by decrease the thiobarbituric acid reactive substance (TBARS) produced from lipid peroxidation of liver microsomes induced by Fe++/ascorbate, Fe++/H2 O2 and CCl4 model systems. All algal extracts had significant effect to prevent the production of TBARS in all oxidizing model systems and this phenomenon was increased by increasing their concentration. The values of inhibition % of TBARS generate from Fe++/ascorbate, Fe++/H2 O2 and CCl4 model system by Dunaliella salina were 100, 94.43 and 90.9% respectively, (at 15 min) at concentration level 200 ppm, while the inhibition values were 98.49, 89.8 and 88.8% at 100 ppm. This extract possesses higher antioxidant activity with average 2 times than the BHT at the same concentration level (100 ppm). On the other hand, mutant strains extract of Scenedesmus dimorphus, Scenedesmus acutus and Chlorella ellipsoida showed higher antioxidant activity than the normal cells extracts. The most of all algal extracts showed more potent as an antioxidant than the BHT which, is one of the powerful synthetic antioxidant agent. The antioxidant activity of algal extract and BHT against the induced lipid peroxidation in all model system were in the following descending order: Dunaliella salina > Sc. dimorphus mutant = Chlorella mutant > Sc. dimorphus normal > Chlorella normal > Sc. acutus (mutant) > Sc. acutus (normal) > BHT. The antioxidant activity of algal extracts on induced lipid peroxidation in different model system was dependent on the chemical composition of their extracts which containing mainly the carotenoids, tocopherol and vitamin C. These substances can protect lipid peroxidation in all model system by different mode of action. Therefore, micro algae extracts inhibited the lipid peroxidation products by scavenging reactive oxygen species (OH, O¯ and 1O2) and chain reaction breaking consequently its protect bodies from harmful effect of their substances.

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