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Journal of Medical Sciences

Year: 2003  |  Volume: 3  |  Issue: 5  |  Page No.: 395 - 400

Evaluation of Diuretic Activity of Ipomoea aquatica (Kalmisak) in Mice Model Study

M.M. Mamun, M.M. Billah, M.A. Ashek, M.M. Ahasan, M.J. Hossain and T. Sultana

Abstract

The diuretic activity of the methanol extract of Ipomoea aquatica was investigated in the Swiss albino mice. A dose dependent diuretic activity of 1.93 and 2.44 of the extract was observed at a dose of 250 mg kg-1 and 500 mg kg-1 body weight, respectively. Good diuretic activity was evident till the fifth hour when mice were orally administrated with the extract at these concentrations. The diuretic activity of the extract was compared with that of the standard drug fursemide at a dose of 500 μg kg-1 body weight. The maximum diuresis observed with both the doses at the first hour of study indicated its rapid onset of diuretic action. The diuretic responses with its electrolyte excretion potency of the extract were highly remarkable in comparison with control animals. The extract, at doses of 250 and 500 mg kg-1 show a dose dependent increase in volume of urine with moderate increase in Na+ and ClB excretion, accompanied by the excretion of K+. In all cases the excretion of electrolytes and volume of urine increased was higher than the standard diuretic, fursemide.

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