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Journal of Medical Sciences
Year: 2003  |  Volume: 3  |  Issue: 3  |  Page No.: 240 - 244

Antibacterial Activity and Cytotoxicity of Three Lectins Purified from Cassia fistula Linn. Seeds

M. Abbas Ali, M. Abu Sayeed and Nurul Absar    

Abstract: Three lectins CSL-1, CSL-2 and CSL-3, purified from the Cassia fistula seeds were tested for their antibacterial activities against 14 pathogenic bacteria using 30 μg/disc. The lectin CSL-3 was found to be active against all of the bacterial strains and showed strong activity against Bacillus megaterium, Streptococcus β-haemolyticus and Shigella boydii. The lectin CSL-2 showed poor activity against most of the bacterial strains and has strong activity against only Streptococcus β-haemolyticus. But the lectin CSL-1 was found to be inactive against all the bacterial strains except Streptococcus β-haemolyticus and Sarcina lutea. All the lectins affect significantly the mortality rate of brine shrimp. Among them CSL-2 was found to be highly toxic (6.68 μg ml-1) followed by CSL-1 (10.47 μg ml-1) and then CSL-3 (13.33 μg ml-1).

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