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Journal of Medical Sciences
Year: 2002  |  Volume: 2  |  Issue: 4  |  Page No.: 198 - 201

In vitro Antibacterial Activity of 2, 2-Diamino-1-Azavinyl Aminoamide

J. A. Khanam, M. Akhtaruzzaman, A. Y. K. M. Masud Rana and M. Shajahan    

Abstract: A new compound 2,2-diamino-1-azavinyl aminoamide was synthesized by the reaction of hydrazine hydrate and urea. It was screened against eleven bacteria for its antibacterial activity. At dose 30 μg disc-1 tested compound shows diameter of zone of inhibition within the range 12-24 mm against all of the tested bacteria which was found to be larger range as compared to kanamycin (27-36 mm) at the same dose. Minimum inhibitory concentration was obtained against Shigella dysenteriae, Salmonella typhi and Sarcina lutea with in the range of 8-16 μg ml-1. The brine shrimp lethality of the compound was found to be 8.12 μg ml-1. The tested compound possesses a pronounced cytotoxic effect as observed from mortality rate of brine shrimp nouplii but the compound (10 mg kg-1) had no major toxic effect on hematological parameters in mice. In conclusion, the tested compound, 2,2-diamino-1-azavinyl aminoamide may be considered as a new one having potential antibacterial activity with less toxic effect on hematological parameters.

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