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Journal of Medical Sciences

Year: 2001  |  Volume: 1  |  Issue: 6  |  Page No.: 368 - 371

Toxicological Studies of Two Novel Compounds Isolated from Streptomyces Species

A. S. M. Anisuzzaman, Naoki Sugimoto, M. S. A. Bhuiyan, Golam Sadik and M. A. Gafur

Abstract

The chloroform extract and the two novel compounds streptmysone-A (I) and streptomysone-B (II) of the Czapek-Dox (alkaline) culture filtrate of the Streptomyces species were studied for cytotoxic and acute toxicity activities. The cytotoxic activity of the compounds and the extract was determined by brine shrimp lethality bioassay while the acute toxicity study was performed on Swiss albino mice. The LC50 values of chloroform extract(CHCl3), compound (I) and (II), and standard ampicillin trihydrate were found to be 3.89, 6.31, 125.8 and 6.31Fg ml-1, respectively. The LD50 values were found to be 66.34 and 79.49mg kg-1 for the compound (1) and (II), respectively.

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