Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Journal of Medical Sciences
Year: 2001  |  Volume: 1  |  Issue: 6  |  Page No.: 368 - 371

Toxicological Studies of Two Novel Compounds Isolated from Streptomyces Species

A. S. M. Anisuzzaman, Naoki Sugimoto, M. S. A. Bhuiyan, Golam Sadik and M. A. Gafur    

Abstract: The chloroform extract and the two novel compounds streptmysone-A (I) and streptomysone-B (II) of the Czapek-Dox (alkaline) culture filtrate of the Streptomyces species were studied for cytotoxic and acute toxicity activities. The cytotoxic activity of the compounds and the extract was determined by brine shrimp lethality bioassay while the acute toxicity study was performed on Swiss albino mice. The LC50 values of chloroform extract(CHCl3), compound (I) and (II), and standard ampicillin trihydrate were found to be 3.89, 6.31, 125.8 and 6.31Fg ml-1, respectively. The LD50 values were found to be 66.34 and 79.49mg kg-1 for the compound (1) and (II), respectively.

Cited References   |    Fulltext    |   Related Articles   |   Back
   
 
 
 
  Related Articles

 
 
 
 
 
 
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility